George Emil Palade
Acting at the interface of DNA and chromatin, these proteins are commonly perceived as chemically intractable as they often operate as molecular scaffolds in multi-protein complexes, lack a pharmacologically tractable enzymatic domain, or function via protein-protein or protein-DNA interactions. Targeted protein degradation combines the kinetic advantages of small molecule approaches with the holistic nature of genetic perturbation strategies and is thus ideally suited to measure and interpret acute changes in gene regulatory programs and assay for new transcriptional addictions in cancer.
We are aiming to apply this technology to a comprehensive set of transcriptional regulators implicated in cancer as well as further develop strategies that enable genome-scale applications. Forward genetic screens based on RNA interference or insertional mutagenesis have successfully been deployed to identify novel therapeutic targets, elucidate the mechanism of action of drugs and discover biomarkers for patient stratification.
Georg E. Schulz
We designed a protein-domain focused, deep-coverage sgRNA library that targets genes implicated in transcriptional regulation that we will deploy in order to identify novel dependencies in transcriptionally dysregulated cancers. Focusing on chromatin-acting small molecules, we want to elucidate resistance mechanisms as well as drug-sensitizing perturbations to inform patient stratification as well as rational drug combinations. Gene-drug interactions derived from such screens will enable us to discover novel insights in aberrant transcriptional regulation as well as to understand connectivity between different gene-regulatory networks implicated in the pathophysiology of cancer.
In , Georg Kodek was appointed a district court judge in Vienna. After serving at the superior court of Eisenstadt and the Vienna Court of Appeals, in he was appointed to the Austrian Supreme Court.
In addition, he published and lectured at the University of Vienna where he obtained the venia legendi in In he was appointed professor of civil and commercial law at WU Vienna when that school started to offer a full law curriculum. In addition to his duties at the court and at university, he has lectured extensively both in Austria and abroad.
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He also served as court-appointed or retained expert on foreign law in a number of high-profile foreign lawsuits and arbitration proceedings, appearing before courts in Germany, Liechtenstein, Switzerland, the United Kingdom, the United States and the British Virgin Islands. In he was visiting researcher at Brisbane University. De gecombineerde citaties worden alleen voor het eerste artikel geteld. Samengevoegde citaties. Het aantal in de tabel 'Geciteerd door' omvat citaties van de volgende artikelen in Scholar.
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